Response by Liu and Sun to Letter Regarding Article, "Plasma Levels of Fatty Acid-Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes: A 22-Year Prospective Study".
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چکیده
Response by Liu and Sun to Letter Regarding Article, “Plasma Levels of Fatty Acid– Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes: A 22-Year Prospective Study” In Response: We appreciate Menzaghi et al comments on our prospective cohort analysis on high-molecular-weight adiponectin and cardiovascular disease mortality among diabetic patients. Menzaghi et al proposed some possible reasons for interpreting the discrepancy between his and our studies. In the Mendelian randomization analysis in Menzaghi et al study, a single-nucleotide polymorphism was used as the instrumental variable, whereas our study used a genetic risk score (including 19 single-nucleotide polymorphisms) which could help obtain more precise causal estimates because scores summarize more genetic determinants of a trait than any single single-nucleotide polymorphism. We acknowledge that we may not have an adequate power for the Mendelian randomization analysis and therefore described the Mendelian randomization analysis as secondary and exploratory in our study. In addition, the 2 studies had very different population profiles, although a causal relationship should be demonstrated in all individuals unless there were interactions by the characteristics that were distinct between the 2 study populations. We agree that more extensive research with large sample size is needed, especially for the Mendelian randomization analysis. Disclosures None.
منابع مشابه
Plasma Levels of Fatty Acid-Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes: A 22-Year Prospective Study.
OBJECTIVE To examine select adipokines, including fatty acid-binding protein 4, retinol-binding protein 4, and high-molecular-weight (HMW) adiponectin in relation to cardiovascular disease (CVD) mortality among patients with type 2 diabetes mellitus. APPROACH AND RESULTS Plasma levels of fatty acid-binding protein 4, retinol-binding protein 4, and HMW adiponectin were measured in 950 men with...
متن کاملPlasma Levels of Fatty Acid–Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes
متن کامل
Letter by Menzaghi et al Regarding Article, "Plasma Levels of Fatty Acid-Binding Protein 4, Retinol-Binding Protein 4, High-Molecular-Weight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes: A 22-Year Prospective Study".
Letter by Menzaghi et al Regarding Article, “Plasma Levels of Fatty Acid–Binding Protein 4, Retinol-Binding Protein 4, High-MolecularWeight Adiponectin, and Cardiovascular Mortality Among Men With Type 2 Diabetes: A 22-Year Prospective Study” To the Editor: We read with interest the article on the paradoxical association between high-molecular-weight (HMW) adiponectin and cardiovascular mortali...
متن کاملEffect of Saffron Extract and Aerobic Exercises on Troponin T and Heart-Type Fatty Acid Binding Protein in Type 2 Diabetes Patients
Objective: Exercise and nutrition as life style modification strategies for the prevention and control of diabetes are considered. The aim of present study was to assess the effects of saffron consumption and aerobic exercises on serum levels of Heart-type fatty acid binding protein (HFABP) and Troponin T in type2 diabetes (T2DM) patients. Materials and Methods: This study was a quasi-experime...
متن کاملThe Effect of 8 Weeks Interval Exercises and Vitamin D Supplementation on Plasma Levels of Dipeptidyl peptidase-4 and Retinol Binding Protein 4 in Overweight Women
Abstract Over weight is one of the most important public health concerns and the most common fat metabolism disorder in humans the purpose of this study was to compare the effect of eight weeks of interval training and vitamin D intake on DPP4 and RBP4 plasma levels of overweight with mean age of 39.92±4.15 , height 159.25±3.8 cm weight 72.73 kg /m2 in this study , 40 subjects were selected pur...
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عنوان ژورنال:
- Arteriosclerosis, thrombosis, and vascular biology
دوره 37 5 شماره
صفحات -
تاریخ انتشار 2017